Renagel cautionary labels.
Information about Renagel.
Avoid taking any other medicines within 1 hour before or 3 hours after you take RenagelSevelamer can bind to other medications and make them less effective.
The active ingredient in Renagel Tablets is sevelamer hydrochloridea polymeric amine that binds phosphate and is meant for oral administrationSevelamer hydrochloride is poly(allylamine hydrochloridecrosslinked with epichlorohydrin in which forty percent of the amines are protonatedIt is known chemically as poly(allylamine-co-N,Ndiallyl-1,3-diamino2-hydroxypropanehydrochlorideSevelamer hydrochloride is hydrophilicbut insoluble in waterThe structure is represented in Figure 1.
Renagel is used to control hyperphosphataemiahigh blood phosphate levelsin adults on dialysisa blood clearance technique used in patients with kidney diseaseIt can be used in patients undergoing haemodialysisdialysis using a blood filtration machineor peritoneal dialysiswhere fluid is pumped into the abdomen and an internal body membrane filters the bloodRenagel should be used with other treatments such as calcium or vitamin-D supplements to control the development of bone disease.
A risk management plan has been developed to ensure that Renagel is used as safely as possibleBased on this plansafety information has been included in the summary of product characteristics and the package leaflet for Renagelincluding the appropriate precautions to be followed by healthcare professionals and patients.
PregnancyNot absorbed systemically following oral administration and maternal use not expected to result in fetal exposure to the drug.
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renagel genzyme , prescription only, is sevelamer hydrochloride, a polymeric phosphate binder intended for oral administration.