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The therapeutic benefits achieved with CARDIZEM are believed to be related to its ability to inhibit the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle.
Do not be alarmed by this list of possible side effectsYou may not experience any of them.
Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with CARDIZEMsee WARNINGS
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Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levelsCoadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possibleand alternative therapy considered.
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